Intravenous immunoglobulin therapy for hyperbilirubinemia caused by Rhesus hemolytic disease.
نویسندگان
چکیده
A nine-hour-old term small for date male newborn weighing 1850 g delivered by Cesarean section to an 'A' rhesus negative mother with an Rh antibody titre of 1:128, presented with pallor, icterus and mild hepatomegaly. Cord blood reports revealed an indirect serum bilirubin of 3.7 mg/dl, reticulocyte count 9%, platelet count 120,000/cu mm, hemoglobin (Hb) 9.3 g/dl, a positive direct Coomb's test and 'A' Rh +ve blood group. Indirect serum bilirubin at 10 hours of age was 6.7 mg/dl.
منابع مشابه
فراوانی بیماری همولیتیک متعاقب تعویض خون در 96 نوزاد
Background: ABO incompatibility hemolytic disease of the newborn is a common cause of clinical jaundice and causes two-thirds of the hemolytic disease in newborns. This study was undertaken to determine the frequency of ABO incompatibility hemolytic disease and its complications in newborns undergoing exchange transfusion.Methods: This prospective and descriptive study was performed in jaundice...
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Newborn infants with maternal-fetal ABO incompatibility are at a greater risk for developing subsequent significant hyperbilirubinemia, and therefore, prediction of probable risk factors, such as the degree of hemolysis, gains importance. In this study, we aimed to evaluate the effect of fetal-neonatal blood group on the severity of hemolysis and jaundice due to maternal-fetal ABO incompatibili...
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OBJECTIVE To evaluate whether the use of intravenous immunoglobulin in newborn infants with isoimmune hemolytic jaundice due to Rh and ABO incompatibility is an effective treatment in reducing the need for exchange transfusion. METHODS This study included all direct Coombs' test positive Rh and ABO isoimmunized babies, who admitted in the Neonatal Intensive Care Unit of Ghaem Hospital of Mash...
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BACKGROUND Despite limited data, international guidelines recommend the use of intravenous immunoglobulin (IVIg) in neonates with rhesus hemolytic disease. OBJECTIVE We tested whether prophylactic use of IVIg reduces the need for exchange transfusions in neonates with rhesus hemolytic disease. DESIGN AND SETTING We performed a randomized, double-blind, placebo-controlled trial in neonates w...
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عنوان ژورنال:
- Indian pediatrics
دوره 31 10 شماره
صفحات -
تاریخ انتشار 1994